Reviewers & Editors Share the Secret Sauce

Book Reviews / Writing & Publishing

Publishing Your Medical Research, 2nd Edition reveals the secret sauce for maximizing the palatability of your manuscript submissions.

Edge reviews have featured exceptional books about the mechanics, inspiration, process, and editing of writing. What differentiates this offering by Daniel Byrne, MS, is data from two rounds of surveys of reviewers and editors identifying the most common flaws of submitted manuscripts that lead to revisions and rejections. Complete with figures that analyze top concerns. This data from inside the peer review machine is the key ingredient well-paired with practical guidance about how to avoid mistakes at each step from the initial design and implementation of research through reply to reviewers.

Byrne is a biostatistician and has more than two decades’ experience teaching and consulting in a Master’s of Science in Clinical Investigation program in which all students – most of whom are physician-scientists – develop, conduct, and publish research projects. Virtually all seek him out for stats consultation and pragmatic guidance. As a result, the core recipes in his book provide sufficient detail that a new cook can garner everything they need to craft a solid paper themselves.

We particularly like these tables and figures (from among more than 50):

  • Self-Education Reading List for Medical Researchers, a solid starting inventory for what should be on the bookshelves of academic investigators and teachers
  • Reviewers’ most common criticisms of manuscripts
  • Editors’ most common criticisms of manuscripts
  • How to avoid annoying a reviewer/an editor
  • Elements of a good title
  • Sentence beginnings to avoid/use sparingly
  • Suggestions for resubmitting
  • How a paper fills a niche in the literature
  • Manuscript section that is most often responsible for rejection
  • Frequency of presentation problems
  • Internal peer review form

And dozens of additional pointers.

If you are refining your writing or research, or teaching others to do so, you won’t go wrong to have a copy of this book to supplement conventional academic writing guides. Don’t be surprised if it becomes the most referenced one on the shelf.

Conflict of interest: Dr. Byrne is faculty at Vanderbilt, the operational home of Edge for Scholars. So far he doesn’t give us any of the royalties. We can always hope – the Keurig needs supplies.

One-Minute Writing Tuneup: Don’t Dangle Your Modifiers Off a Cliff

Writing & Publishing

Modifiers add description, context, and pizzaz to nouns, verbs, and other parts of a sentence. As well as the adjectives and adverbs you’re probably familiar with, verbal phrases function as modifiers too. Verbal phrases take a verb and make it function as a noun, adjective, or adverb.

Examples of verbal phrases used as modifiers:

Using survey data, we measured the effects of the intervention. (How did we measure the effects? We used survey data.)

After preparing the gel, the postdoc denatured the proteins. (When did the postdoc denature the proteins? After preparing the gel.)

We hired a biostatistician to analyze the data. (Why did we hire a biostatistician? To analyze the data.)

Not a modifier’s happy place.

But all modifiers are afraid of heights, and don’t like to be dangled off cliffs. A “dangling modifier” is a modifier that has nothing in the sentence to modify, or appears to modify something the author doesn’t intend it to.

Examples of dangling modifiers:

Incorrect: After reading the article cited, the hypothesis remains unconvincing.
Wait, who finds it unconvincing? Is the hypothesis having an existential crisis?
Correct: After reading the article cited, I still find the hypothesis unconvincing.

Incorrect: Not having used the correct medium, the experiment failed.
Wow, experiments can pick their own growth medium?
Correct: The student didn’t use the correct medium, so the experiment failed.

Incorrect: To investigate the phenomenon, a study was designed.
Yes, but who is actually doing the study?
Correct: To investigate the phenomenon, we designed a study.

As you can see from the last example, passive voice can easily lead to dangling modifiers. (More on that next time.)

To avoid dangling modifiers, make sure every verbal phrase in a sentence connects to the person or thing doing the action. Keep special vigilance at the beginnings of sentences. Avoid passive voice where you can.

Related Resources:

Practical Writing Advice from a Writing Teacher

Making Writing More Memorable and Persuasive 

An Entertaining & Robust Writing Roundup

Read More

Biomedical Editor: Grammar Tip: Dangling Modifiers

Duke Graduate School Scientific Writing Resource: Dangling Modifiers in Scientific Editing

Purdue Online Writing Lab: Dangling Modifiers and How to Correct Them

 

You MUST Read Dreyer’s English

Writing & Publishing

If Strunk and White is a subtle and respectable Merlot, Dreyer’s English is a Cosmopolitan: light, witty, and slightly pink. Reading this style guide is like going to party with your snarky friend to critique everyone from the bar. Dreyer makes you feel like part of the in-crowd, while schooling you on proper writing style. Instead of the mentoring tone of previous style guides, this one provides a series of fabulous and clear suggestions with a running erudite comedy in the footnotes.

You may think saying a style guide is comedic is going too far, but while I was reading it, my kids came in to ask why I was laughing so hard. I picked it up after I had submitted my R01 for mentor feedback, and it was a delight to be reminded others also struggle with corralling difficult phrases into concise sentences. With my next set of R01 revisions, I was refreshed and able to excise extraneous words with new fervor.

I bought the book in hardback; honestly, it was worth it.  If you haven’t already started a collection of books on writing, you may want to borrow it from the library. It’s a delightful read. The book size and paper thickness of the first edition made me feel scholarly with each flip. I moved through his examples while eagerly awaiting his next famous-writer name drop.  His racy examples make the rules stick in your memory. After a few chapters you will never again use the word ‘really’ in text. Grab a cup of tea, or your favorite mixed drink, find a spot where your laughing won’t disturb others, and enjoy.

Additional Resources

Edge Writing Resources Roundup

Practical Writing Advice from a Writing Teacher

One-Minute Writing Tuneup: Comprise vs. Compose

Writing & Publishing

“Comprised of” should never exist in formal writing.  Arguably, the construction is used so much now that sooner or later, style guides will accept it, but not yet.

First, some background. Per the Cambridge Dictionary, Comprise means “to consist of or to be made up of”; i.e., it is the whole.  Compose, sometimes the better alternative, means “to form or make up something [from multiple parts or components].” In a sentence, moving from the whole to the parts uses comprise, while moving from the parts to the whole uses compose.  Example: “The team comprises ten members,” but “Ten members compose the team.”

In the following sentence, try replacing comprised with its synonym contained:

*The experiment was comprised of steps A, B, and C. = *The experiment was contained of steps A, B, and C.

You’d never use the second one, so don’t use the first.

You can rewrite the sentence as “The experiment was composed of steps A, B, and C.”  This is okay, but gets into another problem—passive voice. (Watch for a blog on that soon.)  In this case, because the sentence leads with the whole and ends with the parts, comprised is in fact the best option; it just needs to stand alone. “The experiment comprised steps A, B, and C.”

Use the comprise/compose pair correctly for your writing to comprise clarity and readability.

Related Resources:

Tips for Writing Scientific Manuscripts

Paper-Writing Checklists to Prevent Headaches Down the Road

Top Ten Productivity Tips for More Productive Writing, Revising & Editing

One-Minute Writing Tuneup: Correcting Comparisons

Writing & Publishing

A rule to instantly improve your writing: “Compared to” (or “compared with”) never replaces “than” without a sentence rewrite.

This construct is common in academic work, and misuse is understandable. Often the sentence does make a comparison. However, using “compared to” in place of “than” inevitably leads you to compare the wrong things.

Take this example:

*Patients who took Drug A experienced greater improvement in symptoms compared to those who took Drug B.

The placement of “compared to” in this sentence suggests the reader should compare improvement to patients, when the comparison intended is patients who took Drug A and patients who took Drug B. We naturally want a participle like “compared” to modify the closest noun, in this case, “improvement.” Placing the items compared at the opposite ends of the sentence breaks this grammatical link and makes your reader work harder—never a good thing.

Two fixes are available:

  1. Patients who took Drug A experienced greater improvement in symptoms than those who took Drug B.
  2. Compared to patients who took Drug B, patients who took Drug A experienced greater improvement in symptoms.

Notice “compared to” now modifies “patients” in the second example.

Both “than” and “compared to” work to compare things, but must be treated differently. Improve your writing by not using them interchangeably.

Related Resources:

The Write Rules

Writing in Academia: An Interview with Helen Sword

11 Tips to Increase your Writing Productivity

Getting Your Ducks in a Row for that First Big Grant Submission

Writing & Publishing

So you are sailing high with your K career development award ready to pounce on your next grant submission!  But what do you need to reach that next milestone, i.e. “independent” funding such as a R01—the currency of academic medical research?  Well, you better start thinking about it.  You want to get that grant in as early as possible so that you don’t have a funding gap after your K award.  And remember to take into account the resubmission time for additional data generation to strengthen your application.  And you can’t forget about how long it can take from that point sometimes—beyond one year for fundable and/or borderline fundable scores depending on the federal powers that be.

So what do you need to be successful?  Well of course, you need an awesome hypothesis and research plan.  That’s your science, people, and hopefully you are all over that.  Write it, live it, get others to read it.  However, there is much more—are you independent, does your department support you, do you have space and equipment of your own?  Funding is so tight these days that you need to convince reviewers that you have EVERYTHING to succeed on top of great science, even as a new investigator.  Believe me, I have been there and done it.  I fought the battle, and it was cumbersome.  The smallest things can flip you from “sorry, so close” to “congrats on your funding.”

But as we recently discussed at COMPASS, a peer mentoring group at Vanderbilt, getting to that point can be very challenging.  Priorities can change in departments, particularly with changes in leadership.  Promises can be broken.  Your requests can be lost in the shuffle.  You can’t find the right people to work in your lab and are unsure how to even look for them.  What we learned from all of this and others’ past experiences is that you need to take some chances, spend some funds, and most importantly advocate for yourself or have others do it for you.  But how do you let your boss know that you need some help which will make you successful?  There is a fine line between being the broken record and having that record being thrown out—you need to sing a slow and steady song about your needs.

But sometimes your song may not be heard.  If you find your requests and concerns are falling on deaf ears, get some help.  Recruit other faculty in your department and your research head to support your cause.  If that doesn’t work or you need further evidence to make a case, turn to your mentoring committee.  And make sure that committee is awesome—tough, tenured faculty that know the system inside and out and believe in you.  I say this because they can be your best advocate.  If they are sympathetic to your cause and support your needs to be successful, have them write a letter.  Signed by all of them.  Sent to whomever it needs to go to—Lab Director, Director of Research, Chair, Division Head, etc.  And remind your bosses why you are an asset to your department and what you can provide to make it successful.  And do your part as much as you can with early publications, positive grant reviews, talks at national conferences, and other measures of productivity.

You are on a long trek that can’t be done in isolation.  Utilize those around you to help you be successful and advocate for yourself when you can.  No one told you this job was much more than science . . .

Publishing Null Results

Doing Research / Writing & Publishing

Nearly every scientist has felt the frustration of pouring effort, money and (sometimes) tears into a project only to get null results. The elusive p<0.05 decides whether results get published or not—the oft-mentioned file drawer problem. Others have explained better than I can why this is a problem. Rather, I’d like to contribute some tips I’ve picked up on how to publish null results.

  • Combine results with a significant result. If the story of the paper allows it, consider adding the null results to another related analysis and publishing one big paper. I’ve had some success with this myself, where I decided to include three analyses of biomarkers that were non-significant with one that was.
  • Consider different journals. There is a bias to not even review null results. So consider other options such as open access journals or lower tier journals. The science still gets out there and a publication is better than no publication. Some journals specifically focus on null results such as PLOS One’s Missing Pieces and the Journal in Support of the Null Hypothesis. While I personally haven’t tried any journals focusing on null results, I have had some success looking beyond the top tier journals in my field and even considering journals in other fields.
  • Don’t give up easily, but know when to fold. One part of publishing null results is getting used to rejection, particularly not even having papers reviewed. If you know your methods are solid and your science strong, don’t give up. Human beings are prone to bias and this likely includes a bias against wanting to publish null results (particularly if it counters a favored hypothesis or theory). Be mindful, though, of how much time you have to spend reformatting for different journals compared to the time you need to spend on other responsibilities. There is no shame in giving up once you’ve made a good effort.
  • When designing your study or analysis, try to design it in such a way that even null results are interesting. This, obviously, won’t help after you’ve analyzed your data but you can still consider why the null results would be useful.
  • Add power analyses. I’ve tried this myself and it does seem to help. Showing that your study was powered to find a typical effect size for your field helps establish that the result wasn’t just because the study was too small or had too much error.

These strategies don’t negate the root cause of the file drawer problem, namely a publication system that wants flashy, highly citable papers, and null results just aren’t that. I don’t have any good suggestions for how to solve the systemic parts of the problem except what others have already said: more journals that specifically publish null results or having current journals commit to publishing more null results or abandoning p-values altogether. Hopefully these tips will help other new scientists until the field addresses the problem.

How to Review a Paper

Writing & Publishing

Reviewing regularly, even early in your career, lets you stay ahead of the curve of the literature.  Close analysis of a paper benefits your writing as you see examples that do or don’t lead the reader down a logical path to a conclusion, clearly explain the significance of the work, or present data well.  If a paper proves not to be a good example, the experience of making positive suggestions can help you think about how you would avoid their mistakes.

Kathy Gould, PhD, Professor of Cell and Developmental Biology and reviewer of many papers, gave a detailed overview of how to review a paper to a group of Vanderbilt postdocs.  Here are highlights, and some questions to ask yourself:

Can you do it well (and on time)?

When you get the request to review, consider these questions:

  • Am I sufficiently knowledgeable to review?
  • Am I interested in the paper?
  • Do I have a conflict? (Are the authors and I friends or competitors, am I financially conflicted?)
  • Do I have the time? Journals may ask you to return a review within 10 days.

You can say no; opportunities will come around again (and again…).  Whatever you decide, quickly inform the journal so that if you decline, they can move on to the next potential reviewer.

The first pass

Skim the paper to form an initial impression.  Consider:

  • What is the main question addressed?
  • Is it relevant, interesting, and original? (What does it add to the field?)
  • Are the conclusions consistent with the evidence and arguments presented? Do they address the main question posed?
  • Do the figures and tables add to the paper or are they superfluous?
  • Are there any major flaws?

What’s a major flaw?

  • Conclusion is contradicted by the evidence
  • Use of a discredited method
  • Ignoring a process known to have a strong influence on the area under study
  • Insufficient, unclear, or contradictory data
  • Statistically uncompelling
  • Confirmatory data that adds little, if anything, to current understanding
  • Many typos, unclear or ambiguous writing

Next, consider each section separately.  Write down your thoughts as you go; this will become the outline for your review.  Click below to view questions you should ask for:

Now, write your review. Make a coherent argument to the editor about the paper’s suitability for publication in that journal.  In Paragraph 1, summarize the authors’ research, which helps the editor contextualize the paper and adds weight to your judgment (you’ve shown you understand the paper).  You can also use this paragraph to affirm what the authors did well.

Paragraph 2 and further paragraphs explain the contribution of the work and provide a recommendation—but not in so many words.  Remember that you are one of three reviewers, typically, and you could be overruled.  If the authors see that you recommend publication and their paper isn’t published, this puts the journal editor in a bind.  So give your recommendation more subtly by stating whether the premise is interesting/important, the methods appropriate and innovative, and if the data support the conclusions.  Is it of high quality and complete, or are there significant things lacking?  Is the work novel or mainly confirmatory?  Here is also where you will want to summarize any major flaws.

But yes, you will get to recommend whether to publish it.  The recommendation section is generally invisible to authors and typically offers three options: Accept, Revision (major or minor), or Rejection.  Sometimes it asks you to rank the paper instead.  Make sure to support your recommendation with clearly articulated reasons.  Occasionally you’re allowed to be more granular, such as suggesting to publish but wait for space rather than rushing to get it out, or that it would be good for a lower-tier journal, or you can state this in your confidential comments to the editor.  That space is also where you can note suspicions of fraud, plagiarism or unattributed work, or bias.

Other tips

  • Be professional. Reviewing is a core part of working in academic research, so do it well.  (Besides, your own papers need reviewing—maybe by the authors upon whom you’re passing judgement.)  Part of being professional is taking the time to draft and revise your review before you send it in.
  • Understand your role. You are a consultant to the editor. Your job is to evaluate the rigor and originality of the science and the clarity of the writing, not to assess potential impact.  (Impact comes with time.)
  • Be helpful. Suggest changes that will improve the paper.  But also be realistic about suggesting additional experiments or other work.  Not every nit needs to be picked. Don’t be Reviewer 2.  And try not to wind up here.
  • Be organized and clear. The authors need to understand what needs improvement.  It’s helpful to number your points and refer to line and page numbers.
  • Don’t include value-laden adjectives (“terrible,” “crazy”) and try to avoid referring to “the authors”; instead say “the work,” “the data,” etc. Remember how everyone tells you not to take reviews personally?  This helps the authors whose paper you’re reviewing do that.

Further Resources

Cell advice to reviewers

Nature advice to reviewers

From Science Careers: How to review a paper (many senior faculty share how they do it)

The journal you’re reviewing for almost certainly has advice to reviewers online somewhere; if you didn’t receive a copy or a link from the editor, google it up.

This article was written by Rebecca Helton of Edge for Scholars based on a talk hosted by the ASPIRE program.

Research Manuscripts Should Tell Really Good Stories

Book Reviews / Writing & Publishing

Book Review: The Art of Scientific Storytelling by Rafael E. Luna, PhD

Chapter 1: Introduction

Skim or skip. This section promotes the book and the promising ideas it conveys, when many of us (me, me, me) just want to get to the meat of the book. After several pages it reads as blah, blah, blah.

Key takeaways: The author, (who is Executive Director of the National Research Mentoring Network), has golden credentials and oodles of experience to share to help you write better.

Figure 3

Chapter 2: Fashioning Your Scientific Story Using the Basic Elements of Narrative Craft

Here’s the content I expected earlier. If you’re already familiar with narrative arcs, this section will feel familiar. If storytelling form is a new concept, then this can help identify the various narrative structures and prepare you to think creatively about how they apply to a research manuscript.

Figure 3 (at right with modifications) helps make the connection without needing to read the entire chapter. The Essential Toolkit of Storytelling Terms is basic, but does teach how to apply these terms directly to the scientific paper you are writing.

Key takeaways: Lifecycle of a Scientific Story begins with the Introduction, Results Section 1, Results Section 2, Results Section 3, Results Climax, Results Validation, and ends with the Discussion.

Chapter 3: An Order of Operations to Streamline Scientific Storytelling

A bit too wordy when telling stories within the larger story. I would prefer to cut to the chase and lay out the steps needed, which does happen by about the fourth page of the chapter, along with some solid general writing guidelines to consider in early drafts.

Key points are summarized in the following excerpt:

“The Introduction ushers your protagonist into a scene with a major problem/scientific unknown, which sets up your hypothesis. Results Sections 1, 2, and 3 show the protagonist undergoing increasing tension by step-wise experimentation to address the major problem/scientific unknown (overall hypothesis), which drives the reaction forward to its highest tension. The Climax experiment is the critical experiment that is centered on the protagonist and provides the strongest evidence for the major findings in the research study, which drives the reaction toward completion. The Validation step lends the most credibility of the study by making a step that makes your story believable. The Discussion section places your results in the context of the current literature, returning your protagonist to his original scene and showing how he is irrevocably changed.”

Key takeaways: The structure of research narrative mirrors other stories, and you can break it down by section. In fact, you should break it down by section and carefully include essential supporting details.

Chapter 4: Specifics for Writing Each Section (Here are the meat and potatoes!)

In the longest (and best) chapter of the book, we get section-by-section guidance on topics like selecting the best title, abstract essentials (sentence by sentence), storytelling through figures, results, introduction, discussion, and finally revision. These steps read a bit like recipes, and offer concrete and clear guidance about what to include.

The author notes:

“If you remember only two things from this book, it should be the following:

1.) A hypothesis can be defined as Conflict Resolution, which is the basis of all stories, especially Scientific Storytelling.

2.) Boldly state your testable hypothesis in your Title and throughout the text of your manuscript provide scientific evidence to substantiate your hypothesis (or in the urban vernacular: Drop the Mic!).”

Included at the end is a quick-start guide to hosting a Scientific Storytelling workshop of 6-18 participants along with critical analysis questions, which can be helpful even outside of the workshop setting and in solo editing.

Key takeaways: Use this section of the guide when crafting your first draft, then refer back to it throughout the revision process. If you mentor, consider if the Scientific Storytelling framework offers a fresh way to bring out more nuances of the flow of scientific writing.

Additional Resources:

You Need a Shut Up and Write Group Like You Need to Eat

Writing & Publishing

Like eating regular meals, there’s another thing you know you need to do, want to do, have to do, but can hardly find the time for: Writing.  The answer? A delicious serving of a regular writing group with protected writing time on the side. Shut Up and Write is just that: a group that meets weekly and fills up on 25 minutes writing with 5 minute chat breaks in between. Like any meal, make this meetup as fancy or casual as you like by organizing a large group or just grabbing a few select colleagues for a low-key write-in.
Hungry to write? Follow this recipe to cook up your own Shut Up and Write (SUAW) group. Don’t worry too much about the formalities if it’s just a small group, but for larger groups these tips can help keep things on course.

Nutritional Benefits of SUAW

  • Establish a well-balanced academic writing diet by sustaining a consistent routine to finish your writing project.
  • Take advantage of the focus that working away from your office or home can provide while adding steps to your Fitness tracking app.
  • Expand your academic palette aka community.

Ingredients and Preparations

You will need…

  • A place to meet.
  • A recurring day of the week.
  • A recurring time slot.
    • Aim for 2 hours minimum and up to 4 hours if possible.
  • To decide how often to meet.
    • Weekly is best, but every other week can work.
    • Consider duration, some groups run sessions leading up to important deadlines like grant submissions while others are year round.
  • A list of interested individuals to invite.
    • Number will vary depending on space constraints.
  • Incentive.
    • Peer accountability becomes an extra spur to productivity, but free coffee is also good if possible.
  • Go-bag with:

For larger groups consider…

  • An email invitation.
    • Send out at least one week in advance and reminder email 24-48 hours before meetup.
  • Table tents with instructions.
    • Just the facts with key SUAW info for newbies.
  • Room signage.
    • Directional signs can help locate meeting room.

Serving Suggestions for SUAW

Arrive a bit early to set the table. Bring your Go-Bag.

  • Place room signage and table signage if desired.
  • Set your timer for 25 minutes and get to work.
  • Gently ring the chimes when the time is up and time a 5 minutes break.
  • Using the chimes call everyone back to writing for another 25 minute session.
  • Repeat until entire meeting time is up.

This process works well for sponsored groups, less formal peer groups just get up and stretch when the phone alarm goes off.

More Writing Food for Thought

Even if the first meeting has a low attendance, keep spreading the word and keep showing up and writing. Look for others who are also working on dissertation chapters, abstracts, manuscripts or grant submissions to join.

Cooking up your own Shut Up and Write group means you are creating a time and place for yourself and others for professional writing and career development. So find a place, send those emails, and start scavenging for spare power strips. And you know what to do when you get there. Just shut up and write.